AC Immune’s ACI-24.060 Anti-Amyloid Beta Vaccine for Alzheimer’s Shows Positive Initial Interim Safety and Immunogenicity in Phase 1b/2 ABATE Trial
- ACI-24.060 elicited an anti-Abeta antibody response in ABATE’s first, low dose cohort
- ACI-24.060 was generally well tolerated with no safety concerns observed
- With these findings, dosing in the second, higher dose Alzheimer’s cohort has begun
- Screening of cohort of study participants with Down syndrome also cleared to begin
- Further safety and immunogenicity findings from ABATE cohorts expected in H2 2023
- Initial data on amyloid plaque reduction measured via PET imaging anticipated in 2024
AC Immune SA, a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, today announced the first interim safety, tolerability and immunogenicity findings from the Phase 1b/2 ABATE trial of its anti-amyloid-beta (Abeta) vaccine ACI-24.060 in patients with prodromal Alzheimer’s disease (AD). ABATE will now be expanded, as planned, to include individuals with Down syndrome (DS) and to evaluate higher doses in Alzheimer’s patients.