Immatics Presents Preclinical Proof-of-Concept Data for TCR Bispecifics Program IMA401 Targeting MAGEA4/8
- Immatics’ first TCR Bispecific program IMA401 delivers preclinical proof-of-concept demonstrating complete remissions of transplanted human tumors in mice and favorable CMC characteristics
- The IMA401 target, an HLA-A*02-bound peptide derived both from MAGEA4 and MAGEA8, shows >5-fold higher target peptide levels on cancer cells than a commonly used target peptide derived from MAGEA4
- Immatics continues to anticipate submission of an IND application for IMA401 by the end of 2021
Immatics N.V. (“Immatics”), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies, today announced a preclinical data update on IMA401, its lead T cell receptor (TCR) Bispecifics Program. IMA401 is the first product candidate from Immatics’ TCR Bispecifics pipeline, called TCER™ (T Cell Engaging Receptor), and directed against the cancer target MAGEA4/8. Immatics demonstrated specific targeting and T-cell recruitment to target-positive tumors by its proprietary TCR Bispecific molecule, leading to complete remissions of human-derived tumors in xenograft mouse models. The data will be presented at the digital European Antibody Congress 2020 on November 2.