Publication in Cancer Management and Research Underlines the
Potential of Apogenix’ Asunercept for the Treatment of Other
Malignancies Beyond Glioblastoma and MDS
Apogenix, a biopharmaceutical company developing next generation immuno-oncology therapeutics, announced today that a new publication in Cancer Management and Research1 reviews asunercept as a promising treatment option for patients with other malignancies beyond glioblastoma and myelodysplastic syndromes (MDS). Published evidence suggests that CD95 and CD95 ligand (CD95L) play a critical role in maintaining T cell responses in the tumor microenvironment (TME). CD95/CD95L signaling has been shown to promote the escape of tumor cells from immune surveillance and their resistance to available therapeutic options. It further affects the differentiation and infiltration of T-effector cells into the TME, suggesting that CD95L may act as an immune checkpoint. As high levels of CD95L have been detected in tissue samples of patients with melanoma, breast, colon, renal, bladder, prostate, head and neck, pancreatic, and ovarian cancer, the inhibition of the CD95/CD95L pathway with asunercept may represent a promising novel therapeutic approach in cancer immunotherapy.